Expression of NR1 subunit of NMDA receptor and PSD-93/95 in rat hippocampus affected by NR1/NR2 antisense oligodeoxynucleotide

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Expression of NR1 subunit of NMDA receptor and PSD-93/95 in rat hippocampus affected by NR1/NR2 antisense oligodeoxynucleotide

Background Abnormal protein expression of N-methyl-D-aspartate (NMDA) receptors essential subunits (NR1, NR2) and of associated post-synaptic density proteins (PSD-95, PSD-93) were observed in schizophrenic patients (postmortem studies) [1,2]. NMDA receptors containing NNR2A/B subunit associate in vivo at synapses with PSD-93 and PSD-95 [3]. In the present study, we have silenced the expression...

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Morphine-Induced Analgesic Tolerance Effect on Gene Expression of the NMDA Receptor Subunit 1 in Rat Striatum and Prefrontal Cortex

Introduction: Morphine is a potent analgesic but its continual use results in analgesic tolerance. Mechanisms of this tolerance remain to be clarified. However, changes in the functions of μ-opioid and N-Methyl-D-aspartate (NMDA) receptors have been proposed in morphine tolerance. We examined changes in gene expression of the NMDA receptor subunit 1 (NR1) at mRNA levels i...

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Molecular biology of the apteronotus NMDA receptor NR1 subunit.

The complete sequences and expression patterns of the NR1 (aptNR1) subunit of the N-methyl-d-aspartate (NMDA) receptor and its alternative splice isoforms have been determined for the weakly electric fish Apteronotus leptorhynchus. The deduced amino acid sequence of aptNR1 is approximately 88 % identical to the NR1 sequences of other vertebrate. Two of the three alternative splice cassettes pre...

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MMP-7 cleaves the NR1 NMDA receptor subunit and modifies NMDA receptor function.

Matrix metalloproteinases (MMPs) are zinc-dependent enzymes that play a role in the inflammatory response. These enzymes have been well studied in the context of cancer biology and inflammation. Recent studies, however, suggest that these enzymes also play roles in brain development and neurodegenerative disease. Select MMPs can target proteins critical to synaptic structure and neuronal surviv...

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Effect of acute exposure to ethanol on distribution of NR1 subunit of NMDA receptor of glutamate in cerebral cortex of chick embryo

Introduction: There is considerable evidence that glutamate-mediated excitatory neurotransmission plays an important role in mediating the behavioral actions of acutely administered ethanol. The aim of the present study was to investigate the effect of acute ethanol exposure on NR1 subunit of NMDA (n-methyl-d-aspartate) receptor distribution in the cerebral cortex of chick embryo on the 10th...

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ژورنال

عنوان ژورنال: Annals of General Psychiatry

سال: 2010

ISSN: 1744-859X

DOI: 10.1186/1744-859x-9-s1-s147